Our new review paper named “The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders” has been accepted to the International Journal of Molecular Sciences (IF=4.556).

In this review, we analyzed the emerging literature on estrogen receptors and psychiatric disorders in cellular, preclinical, and clinical studies. Specifically, we discuss the contribution of estrogen receptor and estrogen signaling to cognition and neuroprotection via mediating multiple neural systems, such as dopaminergic, serotonergic, and glutamatergic systems. Then, we assess their disruptions and their potential implications for pathophysiologies in psychiatric disorders. Further, in this review, current treatment strategies involving estrogen and estrogen signaling are evaluated to suggest a future direction in identifying novel treatment strategies in psychiatric disorders.

Our new study named “Prediction of psychosis: model development and internal validation of a personalized risk calculator” has been accepted to the Psychological Medicine (IF=5.7).

This study aimed to develop and internally validate a model for predicting the incidence of psychosis in CHR individuals to provide useful assistance in clinical practice. We developed a model that includes social functioning, social cognition, functional decline, verbal memory, and IQ; this model demonstrated fair predictive ability. Using this model, we divided the high-risk groups into three clusters, all of which showed significant differences in the incidence of psychosis. To the best of our knowledge, this is the first study using modern machine learning techniques to model a wide range of variables covering demographic, clinical, and cognitive functions in long-term cohorts spanning more than ten years.

We are always looking for research coordinates or volunteers interested in our work to join the lab. To join, please send a CV, and a one page letter of interest (English or Korean) to Tae Young Lee (tylee@pusan.ac.kr). If you have any questions, feel free to contact us.