The study includes 200 patients with first-episode psychosis or bipolar disorder, 200 individuals at high risk for psychosis or bipolar disorder, and 200 healthy controls between 15 to 35 years of age. Subjects will be recruited from multiple sites including Pusan National University Yangsan Hospital, Inje University Pusan Paik Hospital, Inje University Haeundae Hospital, Kosin University Gospel Hospital, Yangsan Hospital, Bongseng Memorial Hospital, Dong-A University Hospital, Pusan National University. MRI data will be collected at Pusan National University Yangsan Hospital using a 3T Siemens Vida MR scanner. Subjects are assessed on a yearly basis after the baseline, 3 months, six months and one year. We would like to develop a model for predicting transition to psychosis and bipolar disorder by using various biological markers, and present a pluripotent diagnostic system covering various mental disorders at the same time in the direction of RDoC.
Demographics: Family Interview for Genetics Studies (FIGS), Hollingshead Four-Factor Index of Socioeconomic Status (HFIS), Annett Hand Preference Questionnaire (AHPQ)
Clinical: Structured Clinical Interview for the DSM-5-Research Version (SCID-5-RV), Structured Interview for Prodromal Syndrome (SIPS), Bipolar Prodrome Symptom Interview and Scale–Prospective (BPSS-P), Positive and Negative Syndrome Scale (PANSS), Brief Negative Symptom Scale (BNSS), Young’s mania rating scale (YMRS), Calgary Depression Scale for Schizophrenia (CDSS), Global Assessment of Functioning (GAF), Global Functioning: Social and Role Scales (GF).
Self Reports: Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), Aberrant Salience Inventory (ASI), Beck Cognitive Insight Scale (BCIS), The Barratt Impulsiveness Scale – 11 (BIS-11), Connor-Davidson Resilience Scale 10-Item (CD-RISC-10), Childhood trauma and abuse scale (CTAS), Difficulties in Emotion Regulation Scale (DERS), The Ambiguous Intentions Hostility Questionnaire (AIHQ), Embodied Sense of Self Scale (ESSS)
Cognition: Wechsler Adult Intelligence Scale (WAIS), Digit Span, Trail Making Test (TMT), Controlled Oral Word Association Test (COWAT), Wisconsin Card Sorting Test (WCST), California Verbal Learning Test (CVLT), Rey Complex Figure Test and Recognition Trial (RCFT), Auditory Continuous Performance Test (ACPT), Bilateral Complex Finger Tapping (BCFT), Reading the Mind in the Eyes Test (RMET)
Blood: Cortisol, C-reactive protein (CRP), Interleukin 6 (IL-6)
- sMRI: T1w (MPRAGE) and T2w (SPACE) = 0.8mm isotropic resolution
- dMRI: 1.8mm isotropic, TR = 3800ms, b-value = 500(30), 1000(30) and 2500(30)
- fMRI: 2mm isotropic resolution, TR = 2000ms
- MRS: STEAM sequence with TE = 30ms in ACC, Hipp, Striatum, Thalamus
- Neuromelanin: 0.8mm isotropic, TR = 54ms